Contact Info:Email: kandlika@msu.edu  Lab: B327 Life Sciences.  Phone: (517) 353-4648  Fax: (517) 353-8915

Research:

Hypertension is the most important risk factor for cardiovascular disease. My research focuses on understanding the neural mechanisms involved in the development of hypertension. The kidneys are generally considered to have primary responsibility for long-term regulation of blood pressure through control of total circulating blood volume. In addition, sympathetic nervous system activation contributes to the development and maintenance of human essential hypertension and experimental hypertension. In hypertension, sympathetic activity is not uniform; it is enhanced in some systems while not in others. A central hypothesis of my project is that one mechanism by which sympathetic activity affects blood pressure is redistribution of blood volume from vascular compartments of differing compliance (e.g. veins versus arteries; splanchnic versus non-splanchnic organs).

Some techniques used in my research include long-term blood pressure recording (using radiotelemetry and externalized catheters), mean circulatory filling pressure, regional norepinephrine spillover, direct sympathetic nerve recordings, surgical sympathetic ganglionectomy, and in-vivo gene transfer.

Selected Awards:

• American Heart Association Predoctoral Fellowship, 2009-2010
• SEBM Mentoring Award, 2009
• Data Sciences International Travel Award at 2nd Cardiovascular Control Conference, India, 2008
• SEBM's Young Investigator Award at Experimental Biology, San Diego, CA, 2008
• ASPET Graduate Student Travel Award at Experimental Biology, San Diego, CA, 2008
• Travel Award at Hypertension Summer School, Fort Collins, CO, 2007
• Whitaker Foundation Student Registration Grant, IEEE-EMBS, San Francisco, CA, 2004

Abstracts:

Sachin Kandlikar, Anne M Dorrance, Gregory Fink. Early sympathetic denervation of splanchnic organs significantly attenuates hypertension and stroke development in stroke-prone spontaneously hypertensive rats. Experimental Biology, 2009, New Orleans, LA.

Hui Xu, Sachin Kandlikar. BK channel function, venous tone and blood pressure regulation. Experimental Biology, 2009, New Orleans, LA.

Sachin Kandlikar and Gregory Fink. Sympathetic Nervous System in the Development of Mild DOCA-salt Hypertension. 2nd Cardiovascular Control Conference, 2008, Mahabalipuram, India.

Sachin Kandlikar, Xian Cao, David Kreulen, and Gregory Fink. Celiac Ganglia Gene Expression in Mild and Severe DOCA-salt hypertension. Council for High Blood Pressure Research, 2008, Atlanta, GA.

Sachin Kandlikar, Andrew J King, Martin Novotyny and Gregory Fink. Sympathetic activation in the development of DOCA-salt hypertension. Experimental Biology, 2008, San Diego, CA.

Andrew J King, Sachin S Kandlikar, and Gregory D Fink. Nonselective Cyclooxygenase Inhibition Abolishes Chronic Angiotensin II Hypertension in the Rat. Council for High Blood Pressure Research, 2007, Tucson, AZ.

Sachin Kandlikar, Andrew King, Gregory Fink. The splanchnic sympathetic nervous system in DOCA-salt hypertension. Experimental Biology, 2007, Washington DC.

Prior to entering the program:

Darrin M. Hanna, Brooks A. Gross, Sachin Kandlikar, Elizabeth Lempicki, Barbara A. Oakley, and Gabrielle A. Stryker. “Detection of Vesicular Stomatitis Virus using a Capacitive Immunosensor," Proceedings of the IEEE-EMBS 2005 Conference, September 2005, Shanghai, China.

Barbara Oakley, Darrin Hanna, Sachin Kandlikar, Brooks Gross, Gabrielle Stryker. “Cell Lysis in SWLA-2 Hybridomas due to 1 kHz AC Electric Fields,” Proceedings of the IEEE-EMBS 2005 Conference, September 2005, Shanghai, China.

Kandlikar, SS., Oakley, BA., Hanna, DM., Stryker, GA. 2004. "An Examination of the Effect of Decaying Exponential Pulse Electric Fields on Cell Mortality in Murine Spleenocytes, Hybridomas, and Human Natural Killer Cells," Engineering in Medicine and Biology Society. Proceedings of the 26th Annual International Conference of the IEEE 26:2643-2646.

Gross, BA., Kandlikar, SS., Oakley, BA., Hanna, DM., Rusek, A., Stryker, GA. 2004. "An Examination of the Effect of an AC Pulsed Electric Field on Cell Mortality in SWLA-2 Hybridomas," Engineering in Medicine and Biology Society. Proceedings of the 26th Annual International Conference of the IEEE 26:2635-2638.

Publication:

Clark, AK., Kovtunovych, G., Kandlikar, SS., Lal, SK., and Stryker, GA. Cloning and expression analysis of two novel paraflagellar rod domain genes found in Trypanosoma cruzi. Parasitol Res (2005) 96: 312–320.

Memberships:

• The American Society for Pharmacology and Experimental Therapeutics
• American Heart Association
• The American Physiology Society
• Society for Experimental Biology and Medicine