Joseph R. (J.R.) Haywood, Professor and Chairperson
1971,
B.S., University of Kentucky
1972, M.S., University of Kentucky
1976, Ph.D., University of Florida
1977-78, Research Fellow, University of Iowa
1979-1985, Assistant Professor, Pharmacology, University of Texas Health
Science Center at San Antonio
1981-present, Adjunct Scientist, Southwest Foundation for Biomedical Research
1985-1993, Associate Professor, Pharmacology, University of Texas Health
Science Center at San Antonio
1993-2002, Professor, Pharmacology, University of Texas Health Science Center
at San Antonio
2002-present, Professor & Chair, Pharmacology & Toxicology, Michigan
State University
2008-present, Interim Assistant Vice President, Regulatory Affairs Office, Michigan State University
Research Synopsis
Our research program is focused on neurotransmitter regulation and function in the paraventricular nucleus of the hypothalamus in normotensive and hypertensive animals. The paraventricular nucleus serves as a crossroads in integrating homeostatic and allostatic sensory stimuli to regulate the sympathetic nervous system, neuroendocrine function, ingestive behavior, stress responses, and the immune system. Circulating hormones such as angiotensin, aldosterone, and leptin stimulate neural pathways that activate the paraventricular nucleus which, in turn, modulates descending pathways to regulate the sympathetic nervous system and blood pressure. Little is known about neurotransmission and signaling mechanisms in the paraventricular nucleus in response to these chemical and neural stimuli. We use a number of methodological approaches to study the whole animal response to experimental hypertension – microinjection, microdialysis of neural tissue, and biochemical and molecular analyses are employed to understand the relationship between neurotransmitter release and blood pressure control. Models of sodium-dependent hypertension and obesity-related hypertension are studied to gain insights into the factors triggering and sustaining the hypertensive process.
Please feel free to contact me if you have any questions about my research.
Selected Achievements Since 2001
Editorial Boards
- American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
- Hypertension
- Clinical and Experimental Physiology and Pharmacology
American Heart Association (AHA)
Fellow, High Blood Pressure Council, 1986-present
American Physiological Society (APS)
APS Council, 2001-2004
American Society of Pharmacology and Experimental Therapeutics (ASPET)
IUPHAR Representative International Council for Laboratory Animal Sciences, 2003-present
Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC)
Council on Accreditation – Member, 1997-2007
Association of Medical School Pharmacology Chairs (AMSPC)
Chairs Program Committee, 2002-2003
Representative to AAMC Council for Academic Societies, 2004-present
Council, 2006-Present
National Committees
NHLBI Program Project Review Committee, 2003-2007
Samples of Recent Publications
Kenney, M.J., M.L. Weiss and J.R. Haywood. The paraventricular nucleus: An important component of the central regulating sympathetic nerve outflow. Acta Physiol. Scand. 177(1): 7-15, 2003.
Chen, Q.H., J.R. Haywood and G.M. Toney. Sympathoexcitation by PVN injected bicuculline requires activation of excitatory amino acid receptors. Hypertension, 42:725-731, 2003.
Hinojosa-Laborde, C., T. Craig, W. Zheng, H. Ji, J.R. Haywood, and K. Sandberg. Ovariectomy augments hypertension in aging female Dahl salt sensitive rats. Hypertension 44:405-409, 2004.
Hong, J., C. Pesce, W. Zheng, J. Kim, Y. Zhang, S. Menini, J.R. Haywood, and K. Sandberg. Sex differences in renal injury and nitric oxide production in renal wrap hypertension. Amer. J. Physiol. (Heart Circ Physiol), 288: H43-H47, 2005.
Vitela, M., M. Herrera-Rosales, J.R. Haywood, and S.W. Mifflin. Baroreflex regulation of renal sympathetic nerve activity and heart rate in renal wrap hypertensive rats. Amer. J. Physiol. (Regulatory, Integrative and Comparative Physiology). 288: H43-H47, 2005.
VL Brooks, JR Haywood, and AK Johnson. Translation of salt retention to central activation of the sympathetic nervous system in hypertension. Clin. Exp. Pharmacol. Physiol. 32(5-6): 426-32, 2005.
Demers, G, G Griffin, G De Vroey, JR Haywood, J Zurlo, and M Bédard. Animal Research: Enhanced: Harmonization of Animal Care and Use Guidance, Science; 312: 700-701, May 2006.