EFFICACY TESTING
>> Cardiovascular
• Normo and hypertensive animals (surgical and chemical models)
• Radiotelemetry
• Evaluation of neurohormones in blood/other fluids
• Vascular flow and pressure measurements in specific vascular beds (pulm. hypertension models)
• Acute and chronic cardiac electrophysiologic measurements in large animals
• AV-ablated/His Paced dog models
• Rat myocardial infarct/heart failure models
• Chronic heart failure models in large animals
• Acute or chronic cardiac function testing
• Cardiac echocardiography
>> Central Nervous System
• Cognition, locomotor activity, coordination, dialysis
>> Pulmonary
• Exercise-induced effects (including treadmill)
• Respiratory rate, minute volume, capnography, etc.
>>Renal
• GFR, fluid/electrolyte balance, clearance, etc.
>> Autonomic Nervous System
• Including in vivo quantification of sympathetic nervous system activity (norepinephrine spill over technique)
GENERAL TOXICOLOGY (non-GLP)
>> Acute Toxicity
>> Subchronic Toxicity
>> Early Target Organ Identification
>> Gastrointestinal
• Transit time, gastric emptying time, absorption, etc.
• Assessment of drug action on gastrointestinal tract nerve muscle preparations
• Assessment of drug action on peristalsis using the “Trendelenburg preparation” with spatiotemporal analysis of muscle movements.
• Assessment of drug action on visceral sensation using electromyographic measurements of responses to colorectal balloon distention
>> Stroke models
• Ischemic, ischemia-reperfusion
>> Tumor Efficacy testing in mice (both IP and SC models)
• Multiple cell lines
• Experience with SiRNA
SAFETY PHARMACOLOGY (non-GLP)
>> Cardiovascular (BP, HR, ECG, QT/QTc, His-paced models)
>> Central Nervous System (locomotor activity, functional observation battery, coordination, sensory/motor responses, rotorod)
>> Pulmonary (respiratory rate, minute volume, capnography, etc.)
>> Renal (GFR, volume, specific gravity, osmolarity, pH, fluid/electrolyte balance, proteins, cytology)
>> Gastrointestinal (transit time, gastric emptying time)
>> Autonomic Nervous System
PHARMACOKINETIC CHARACTERIZATION
>> Rodent and non-rodent
CUSTOMIZED EVALUATIONS/MODELS
We are fully capable of developing custom models to fit a wide range of research needs.
SPECIES
Mice, rats, rabbits, canines, minipigs, and others developed and implemented as needed.
ROUTES OF ADMINISTRATION
Oral (gavage, capsule, diet, drinking water, etc.); parenteral (IV, IM, SC, IP, etc.); continuous infusion; ocular.